海洋微生物天然药物的发现、生物合成和作用机制研究。
1）海洋微生物活性次级代谢产物的基因组挖掘；
2）活性环肽分子的发现、生物合成及生物工程改造；
3）海洋药物先导化合物的作用机制研究。

2009年毕业于华南农业大学，获博士学位。同年7月到中国科学院南海海洋研究所工作，历任助理研究员、副研究员和研究员（2017年）。其中2016年4月-2017年4月加州大学伯克利分校访学1年。

1.NSFC--山东联合基金重点项目：海洋微生物源新型农用天然产物的挖掘及其生物合成（U23A20107），2024.01-2027.12，255万元，在研，主持。
2.抗癌活性小分子天然产物的生物合成研究（2023B1515120053），区域联合基金重点项目—粤莞联合基金重点项目，2023.11.01---2026.10.31，100万元，在研，主持。
3.“微生物源药物细胞工厂构建与生产示范”项目“微生物源药物底盘发酵性能提升的机制与策略”课题—子课题，（2023YFA0914200），2024.01-2028.12，63万元，在研，主持。
4.JKW项目--课题：抗感染分子的发现及抗感染候选药物的成药性评价（2022-CJQ-ZD-224-11-5），2022.11-2025.05，100万元，在研，主持。
5.优秀青年科学基金项目：天然药物化学（82022067），2021.01-2023.12，120万元，结题，主持。
6.中科院南海海洋研究所“南海新星”项目：含肉桂酸结构单元抗结核环肽化合物的基因组挖掘（NHXX2019SW0101），2019.10-2022.10，100万元，结题，主持。
7.国家自然科学基金面上项目：深海链霉菌 Streptomyces atratus SCSIO ZH16中新颖环肽化合物atramycin的代谢激活及其生物合成机制（31870046），2019.01-2022.12，59万元，结题，主持。
8.国家重点研发计划课题三-子课题：微生物天然产物的智能创制与改良-新结构和新功能天然产物的合成体系的智能创建（2019YFA0901903），2019.01-2023.12，80万元，在研，主持。
9.广东省自然科学基金面上项目：南海深海链霉菌Streptomyce atratus SCSIO ZH16基因组中结构新颖的环肽化合物的挖掘（2018A0303130005），2018.05-2021.04，10万元，结题，主持。
10.国家自然科学基金应急项目：深海放线菌源抗结核抗生素怡莱霉素E的作用机制及体内药效学研究（81741166），2018.01-2018.12，20万元，结题，主持。
11.广东省特支计划：百千万工程青年拔尖人才“基于CRISPR-cas9技术的Streptomyces atratus SCSIO ZH16的基因组挖掘（201528018），2016.01-2018.12. 10万元，结题，主持。
12.国家自然科学基金面上项目：抗菌环肽类抗生素ilamycin的生物合成研究(20872152)，2013.01-2016.12，76万元，结题，主持。
13.国家自然科学青年基金项目：抗肿瘤抗生素海沟霉素A和B的生物合成及其功能基因研究 (31000051)，2011.01-2013.12，19万元，结题，主持。
14.中国科学院创新促进会会员专项基金：2013.01-2016.12，40万元，结题，主持。
15.广州市“珠江科技新星”人才专项基金：抗肿瘤抗生素marthiapeptide A 的生物合成机制及其工程改造(2014J2200089)，2014.04-2017.03，30万元，结题，主持。
16.中国科学院青年人才前沿领域项目：海洋放线菌来源的β-卡啉生物碱  Marinocarboline A-F的生物合成机制研究 (SQ201015)，2011.10-2013.10，8万元，结题，主持。
17.国家科技合作与交流专项：中美合作开发新型-内酰胺酶抑制剂（2011DFA32540)， 2012.01-2014.12，44.93万元，结题，主持。

代表论著：
1.Wang Y, Zhou L, Pan X, Liao Z, Qi N, Sun M, Zhang H, Ju J, Ma J*. Metabolic blockade-based genome mining of sea anemone-associated Streptomyces sp. S1502 identifies atypical angucyclines WS-5995A-E: isolation, identification, biosynthetic investigation and bioactivities. Mar. Drugs 2024, 22(5), 195.
2.Wang Y,# He J,# Alam M. S, Wang F, Shang Z, Chen Y, Sun C, Lu Z, Gao Y, Zhang T, Ju J, Ma J*. Efficient mutasynthesis of “non-natural” antitubercular ilamycins with low cytotoxicity. ACS Synth. Biol. 2024, 13, 940-941.
3.Li Y, Gong N, Zhou L, Yang Z, Zhang H, Gu Y, Ma J*, Ju J*. OSMAC-based discovery and biosynthetic gene clusters analysis of secondary metabolites from marine-derived Streptomyces globisporus SCSIO LCY30. Mar. Drugs 2024, 22, 21.
4.Chen Y, Yang J, Cai C, Shi J, Song Y, Ma J*, Ju J*. Development of marker recycling systems for sequential genetic manipulation in marine-derived fungi Spiromastix sp. SCSIO F190 and Aspergillus sp. SCSIO SX7S7. J Fungi (Basel) 2023, 9(3): 302.
5.Cai C, Chen Y, Zhou L, Gong N, Zhang H, Sun C, Ma J, Ju J*. Antimicrobial polyketides from the marine-derived fungus Spiromastix sp. SCSIO F190. J. Nat. Prod. 2023, 86, 589-595.
6.Yang Z, Liu C, Wang Y, Chen Y, Li Q, Zhang Y, Chen Q, Ju J*, Ma J*. MGCEP 1.0: A genetic-engineered marine-derived chassis cell for a scaled heterologous expression platform of microbial bioactive metabolites. ACS Synth. Biol. 2022, 11, 3772-3784.
7.Zhang H, Chen Y, Li Y, Song Y, Ma J, Ju J*. Secondary metabolites and biosynthetic gene clusters analysis of deep-sea hydrothermal vent-derived Streptomyces sp. SCSIO ZS0520. Mar Drugs 2022, 20(6): 393.
8.Zhang, H.; Zhang, C.; Li, Q.; Ma, J.; Ju, J.* Metabolic blockade-based genome mining reveals lipochain-linked dihydro-β-alanine synthetases involved in Autucedine biosynthesis. Org Lett. 2022, 24, 5535-5540.
9.Chen, Y.; Cai, C.; Yang, J.; Shi, J.; Song, Y.; Hu, D.; Ma, J.*; Ju, J.* Development of the CRISPR-Cas9 system for the marine-derived fungi Spiromastix sp. SCSIO F190 and Aspergillus sp. SCSIO SX7S7. J Fungi (Basel) 2022, 8, 715. doi: 10.3390/jof8070715.
10.Zhang, H.; Chen, Y.; Li, Y.; Song, Y.; Ma, J.; Ju, J.* Secondary metabolites and biosynthetic gene clusters analysis of deep-sea hydrothermal vent-derived Streptomyces sp. SCSIO ZS0520. Mar Drugs 2022, 20, 393. doi: 10.3390/md20060393.
11.Li, J.; Liu, Z.; Hong, M.; Sun, C.; Zhang, T.; Zhang H.; Ju, J.*; Ma J*. Semi-Synthesis of Marine-Derived Ilamycin F Derivatives and Their Antitubercular Activities. Front Chem 2021, 9: 774555. 10.3389/fchem.2021.774555
12.Xie, Q.;# Yang, Z.;# Huang, X.; Zhang, Z.; Li, J.; Ju, J.;* Zhang, H.;* Ma, J.* Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway. J. Hematol. Oncol. 2019, 12(1): 60. doi: 10.1186/s13045-019-0744-3. (IF2019=17.05)
13.Ma, J.;* Huang, H.; Xie, Y.; Liu, Z.; Zhao, J.; Jia, Y.; Zhang, C.; Zhang, Y.; Zhang, H.; Zhang, T.; Ju, J.* Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat. Commun. 2017, 8(1), 391(doi: 10.1038/s41467-017-00419-5). (IF2017=12.353)
14.Ma, J.; Wang, Z.; Huang, H.; Zuo, D.; Luo, M.; Wang, B.; Sun, A.; Cheng, Y.; Zhang, C.; Ju, J.* Biosynthesis of himastatin: Assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps. Angew. Chem. Int. Ed. 2011, 50, 7797-7802. (IF2011=13.455) (high-lighted by Faculty of 1000).
15.Sun, C.; Yang, Z.; Zhang, C.; Liu, Z.; He, J.; Liu, Q.; Zhang, T.; Ju, J.;* Ma, J.* Genome mining of Streptomyces atratus SCSIO ZH16: discovery of atratumycin and identification of its biosynthetic gene cluster. Org. Lett. 2019, 21, 1453-1457.
16.Yang, Z.;# Sun, C.;# Liu, Z.; Liu, Q.; Zhang, T.; Ju, J.;* Ma, J.* Production of antitubercular depsipeptides via biosynthetic engineering of cinnamoyl units. J. Nat. Prod. 2020, 83, 1666-1673.
17.Sun, C.;# Liu, Z.;# Zhu, X.; Fan, Z.; Huang, X.; Wu, Q.; Zheng, X.; Qin, X.; Zhang, T.; Zhang, H.; Ju, J.;* Ma, J.* Antitubercular ilamycins from marine-derived Streptomyces atratus SCSIO ZH16 ΔilaR. J. Nat. Prod. 2020, 83, 1646-1657.
18.He, J.; Wei, X.; Yang, Z.; Li, Y.; Ju, J.; Ma, J.* Characterization of regulatory and transporter genes in the biosynthesis of anti-tuberculosis ilamycins and production in a heterologous host. Mar. Drugs. 2020, 18(4). pii: E216.
19.Yang, Z.; Wei, X.; He, J.; Sun, C.; Ju, J.;* Ma, J.* Characterization of the noncanonical regulatory and transporter genes in Atratumycin biosynthesis and production in a heterologous host. Mar. Drug 2019, 17(10), E560.
20.Xie, Y.; Li, Q.; Qin, X.; Ju, J. ;* Ma, J.* Enhancement of himastatin bioproduction via inactivation of atypical repressors in Streptomyces hygroscopicus. Metab. Eng. Commun. 2019, 8, e00084.
21.Huang, X.; Yang, Z.; Xie, Q.; Zhang, Z.; Zhang, H.; Ma, J.* Natural products for treating colorectal cancer: A mechanistic review. Biomed. Pharmacother. 2019, doi.org/10.1016/j.biopha.2019.109142.
22.Yang, Z.; He, J.; Wei, X.; Ju, J.; Ma, J.* Exploration and genome mining of natural products from marine Streptomyces. Appl. Microbiol. Biotechnol. 2020, 104, 67-76.
23.Li, Y.; Zhang, C.; Liu, C.; Ju, J.;* Ma, J.* Genome sequencing of Streptomyces atratus SCSIOZH16 and activation production of Nocardamine via metabolic engineering. Front Microbiol. 2018, 9, 1269. doi: 10.3389/fmicb.2018.01269.
24.Ma, J.; Zeng, Z.; Chen, Z.; Xu, X.; Wang, X.; Deng, Y.; Lü, D.; Huang, L.; Zhang, Y.; Liu, J.;*Wang, M.* High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. Antimicrob. Agents Chemother. 2009, 53, 519-524.
25.Ma, J.; Zuo, D.; Song, Y.; Huang, H.; Yao, Y.; Li, W.; Zhang, C.; Ju, J.* Characterization of a single gene cluster that is responsible for methylpendolmycin and pendolmycin biosynthesis in the deep sea bacterium Marinactinospora thermotolerans. ChemBioChem 2012, 13, 547-552.
26.Ma, J.; # Liu, J.; #* Lv, L.; Zong, Z.; Sun, Y.; Zheng, H.; Chen, Z.; Zeng, Z. * Characterization of extended-spectrum β-lactamase genes found among Escherichia coli isolates from duck and environmental samples obtained on a duck farm. Appl. Environ. Microbiol. 2012 , 78, 3668-3673.
27.Mo, X.; Ma, J.; Huang, H.; Wang, B.; Song, Y.; Zhang, S.; Zhang, C.; Ju, J.* 11,12-double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme. J. Am. Chem. Soc. 2012, 134, 2844-2847.
28.Xie, Y.; Ma, J.; Qin, X.; Li, Q.; Ju, J.* Identification and utilization of two important transporters: SgvT1 and SgvT2, for griseoviridin and viridogrisein biosynthesis in Streptomyces griseoviridis. Microb. Cell Fact. 2017, 16(1): 177.
29.Shao, M.; Ma, J.; Li, Q.; Ju, J.* Identification of the anti-infective aborycin biosynthetic gene cluster from deepsea-derived Streptomyces sp. SCSIO ZS0098 enables production in a heterologous host. Mar. Drugs 2019, 17, 127( doi:10.3390/md17020127).
30.Mo, X.; Huang, H.; Ma, J.; Wang, Z.; Wang, B.; Zhang, S.; Zhang, C.; Ju J.* Characterization of TrdL as a 10-hydroxy dehydrogenase and generation of new analogues from a tirandamycin biosynthetic pathway. Org. Lett. 2011, 13, 2212-2215.
31.Zhu, Q.; Li, J.; Ma, J.; Luo, M.; Wang, B.; Huang, H.; Tian, X.; Li, W.; Zhang, S.; Zhang, C.; Ju, J.* Discovery and engineered overproduction of antimicrobial nucleoside antibiotic A201A from deep sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652. Antimicrob. Agents Chemother. 2012, 56, 110-114.
32.Zhang, C.; Yang, Z.; Qin, X.; Ma, J.; Sun, C.; Huang, H.; Li, Q.; Ju, J. * Genome mining for mycemycin: discovery and elucidation of related methylation and chlorination biosynthetic chemistries. Org. Lett. 2018, 20, doi: 10.1021/acs.orglett.8b03373.
33.Xie, Y.; Li, Q.; Song, Y.; Ma, J.; Ju, J.* Involvement of SgvP in carbon–sulfur bond formation during griseoviridin biosynthesis. ChemBioChem 2014, 15, 1183-1189 (commented by Faculty of 1000).
34.Mo, X.; Wang, Z.; Wang, B.; Ma, J.; Huang, H.; Tian, X.; Zhang, S.; Zhang, C.; Ju, J.* Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666. Biochem. Biophy. Res. Commun., 2011, 406, 341-347.
35.Gui, C.;# Li, Q.;# Mo, X.;# Qin, X.; Ma, J; Ju, J.* Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis. Org. Lett. 2015, 17, 628-631.
36.Liu, M.; Jia, Y.; Xie, Y.; Zhang, C.; Ma, J.; Sun, C.; Ju, J.* Identification of the actinomycin D biosynthetic pathway from marine-derived Streptomyces costaricanus SCSIO ZS0073. Mar. Drugs 2019, 17, 240.
37.Qin, X.; Xie, Y.; Huang, H.; Chen, Q.; Ma, J.; Li, Q.; Ju, J.* Enzymatic synthesis of GDP--L-fucofuranose by MtdL and Hyg20. Org. Lett. 2018, 20, 1015-1018.
38.Chen, Q.; Ji, C.; Song, Y.; Huang, H.; Ma, J.; Tian, Xi.; Ju, J.* Discovery of McbB, a novel enzyme catalyzing the β-Carboline skeleton construction in the marinacarboline biosynthetic pathway. Angew. Chem. Int. Ed. 2013, 52, 9980-9984 (commented by Faculty of 1000).
39.Wang, B.; Song, Y.; Luo, M.; Chen, Q.; Ma, J.; Huang, H.; Ju, J.* Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation. Org. Lett. 2013, 15, 1278-1281.
40.Xie, Y.; Wang, B.; Liu, J.; Zhou, J.; Ma, J.; Huang, H.; Ju, J. Identification of the Biosynthetic Gene Cluster and Regulatory Cascade for the Synergistic Antibacterial Antibiotics Griseoviridin and Viridogrisein in Streptomyces griseoviridis. ChemBiochem 2012, 13, 2745-2457.
41.Huang, H.; Yao, Y.; He, Z.; Yang, T.; Ma, J.; Tian, X.; Li, Y.; Huang, C.; Chen, X.; Li, W.; Zhang, S.; Zhang, C.; Ju, J.* Antimalarial -carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate. J. Nat. Prod. 2011, 74, 2122-2127.
42.Chen, Z.; Huang, H; Chen, Y.; Wang, Z.; Ma, J.; Wang, B.; Zhang, W.; Zhang, C.; Ju, J.*  New cytochalasins from the marine-derived fungus Xylaria sp. SCSIO 156. Helv. Chim. Acta. 2011, 94, 1671-1676.
43.Zhu, Q.; Chen, Q.; Song, Y.; Huang, H.; Li, J.; Ma, J.; Li, Q.; Ju, J.* Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-L-galactose mutase. Proc. Natl. Acad. Sci. USA. 2017, 114, 4948-4953.
44.Chen, Z.; Zheng, Z.; Huang, H.; Song, Y.; Zhang, X., Ma, J.; Wang, B.; Zhang, C.; Ju, J.* Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07. Bioorg. Med. Chem. Lett. 2012, 22, 3332-3325.
45.Gui, C.; Chen, J.; Xie, Q.; Mo, X.; Zhang, S.; Zhang, H.; Ma, J.; Li, Q.; Gu, Y-C.; Ju, J.* CytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs in Streptomyces. Commun. Biol., 2019, 2, 454 (https://doi.org/10.1038/s42003-019-0699-5).
46.Zhang, Y.; Huang, H.; Chen, Q.; Luo, M.; Sun, A.; Song, Y.; Ma, J.; Ju, J.* Identification of the grincamycin gene cluster unveils divergent roles for GcnQ in different hosts, tailoring the L-rhodinose moiety. Org. Lett. 2013, 15, 3254-3257.
47.Huang, H.; Yang, T.; Ren, X.; Liu, J.; Song, Y.; Sun, A.; Ma, J.; Zhang, Y.; Huang, C.; Zhang, C.; Ju, J.* Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32. J. Nat. Prod. 2012, 75, 202-208.
48.Liu, J.; Wei, S.; Ma, J.; Zeng, Z.; Lü, D.; Yang, G.; Chen, Z. Detection and characterization of CTX-M and CMY-2 beta-lactamases among Escherichia coli isolates from farm animals in Guangdong Province of China. Int. J. Antimicrob. Agents 2007, 29, 576-581.
49.Sun, Y.; Zeng, Z.; Chen, S.; Ma, J.; He, L.; Liu, Y.; Deng, Y.; Lei, T.; Zhao, J.; Liu, J. High prevalence of bla(CTX-M) extended-spectrum β-lactamase genes in Escherichia coli isolates from pets and emergence of CTX-M-64 in China. Clin. Microbiol. Infect. 2010, 16, 1475-1481.
50.Chen, L.; Chen, Z.; Liu, J.; Zeng, Z.; Ma, J.; Jiang H. Emergence of RmtB methylase-producing Escherichia coli and Enterobacter cloacae isolates from pigs in China. J. Antimicrob. Chemother. 2007, 59, 880-885.
51.Deng, Y.; He, L.; Chen, S.; Zheng, H.; Zeng, Z.; Liu, Y.; Sun, Y.; Ma, J.; Chen, Z.; Liu, J. * F33:A-:B- and F2:A-:B- plasmids mediate dissemination of rmtB-blaCTX-M-9 group genes and rmtB-qepA in Enterobacteriaceae isolates from pets in China. Antimicrob. Agents Chemother. 2011, 55, 4926-4929.
专利申请与授权
授权专利：
马俊英、朱湘成、段燕文、鞠建华
1.马俊英、朱湘成、段燕文、鞠建华，一种化合物ilamycin E1 /E2的微生物发酵制备方法， ZL 202110607357.6
2.马俊英、孙长利、刘志永、张天宇、鞠建华，环肽类抗生素及其制备方法和在制备抗结核分枝杆菌药物中的应用，ZL 201910099287.0。
3.马俊英、张华、解青、鞠建华，化合物ilamycin C及其同系物在制备治疗三阴乳腺癌药物中的应用，ZL 201910286615.8。
4.鞠建华、马俊英、黄洪波、张春燕、贾艳玺、李岩，一种定向生产抗结核活性和抗肿瘤活性化合物的基因工程菌株及其应用，ZL 201610885104.4。
5.鞠建华、马俊英、黄洪波、贾艳玺、张春燕，环肽类化合物在制备抗肿瘤药物中的应用，ZL 201610805549.7。
6.鞠建华、朱清华、黄洪波、宋永相、马俊英、李青连，一类核苷类抗生素及其在制备抗菌药物中的应用，ZL 201510460273.9。
7.鞠建华、马俊英、张云、李青连、黄洪波、宋永相、王博、谢运昌，环酯肽类抗生素黑莫他丁的高产菌株及其构建方法，ZL 201410372728.7。
8.鞠建华、张云、黄洪波、刘静、马俊英，一种格瑞克霉素和P-1894B的生物合成基因簇及其应用，ZL 201310118576.3。
9.鞠建华、朱清华、李军、马俊英、田新朋、张长生，一种核苷类抗生素A201A高产菌株及其构建方法，ZL 201110340905.X。
10.鞠建华、张天宇、孙长利、刘志永、马俊英，海洋环肽化合物及其在制备抗结核分枝杆菌药物中的应用，ZL 201911149125.X。
11.马俊英、鞠建华、刘志永、张天宇，化合物ilamycin F 及其应用，ZL 201910335521.5。
申请发明专利：
11． 马俊英、 乔伊君、 鞠建华、 杨佳凡、 宋永相，一株海洋链霉菌及其环八肽化合物在制备抗耐药菌药物中的应用的制作方法， CN 2022105186942。

2023年获得“海洋工程科学技术奖”二等奖（排名第6）
2022年获得广东省自然资源科学技术一等奖（排名第3）
2023年入选中国第十届抗生素专委会委员
2023年入选第五届酶工程与发酵工程专业委员会
2022年入选“海洋与湖沼学会”药学分会第四届理事成员；
2020年获得国家自然科学基金委优秀青年科学基金项目资助；
2019年入选“中国药学会海洋药物专业委员会”青年委员；
2016年入选“广东省特支计划”百千万工程青年拔尖人才；
2014年获得广东省科学技术二等奖（排名第9）；
2013年入选“广州市珠江科技新星”；
2012年入选“中科院青年创新促进会”会员；
2010年获得“广东省优秀博士学位论文”；
2009年获得“华南农业大学优秀博士学位论文”。

Organic Chemistry Froniters、Journal of Natural Product、ACS Synthetic Biology和Organic Chemistry Biology等期刊的审稿人